GH4141 nickel-based superalloy is key material for turbine disks, fasteners and engine cases, which is genially fabricated through traditional casting-forging/rolling processes. In this paper, the hot working behavior of hot-rolled GH4141 superalloy was studied. The hot deformation behaviors of the hot-rolled GH4141 superalloy at deformation temperatures of 1050~1150 °C and strain rates of 0.01~1/s were studied through hot-compression experiments by using Gleeble, and the hot deformation constitutive equation of the alloy during the deformation process was constructed. In addition, based on the microstructure evolution analyses under different deformation conditions, the dynamic recrystallization rules during the hot deformation process were clarified. A dynamic recrystallization fraction model of the alloy was constructed and dynamic recrystallization fraction are able to be accurately predicted by this model. It was found that the dynamic recrystallization fractions were increased with the increase in the deformation-temperature, or decreases in strain rate, or the increases in amounts of deformation. From the viewpoints of degrees of dynamic-recrystallization, the optimal deformation parameters are determined as: deformation-temperature at 1150 °C, and the strain rate 0.01~0.1/s under the same amount of deformation.