Abstract:Infections associated with titanium (Ti)-based implants present significant challenges in clinical treatments, particularly when biofilms already form on the implant surface. Many antimicrobial agents, including antibiotics, metallic nanoparticles, and antimicrobial peptides, have been extensively used to deal with Ti implant infections. However, these chemical approaches suffer from potential toxicity, antibiotic resistance, and poor long-term antibacterial performance. Hence, physical antibacterial surfaces on Ti-based implants have attracted increasing attention. In this work, we present a brief overview of the antibacterial behavior of different surfaces on Ti-based biomaterials against various bacteria only by physical properties of the implants themselves (e.g., nano-topography) or exogenous physical stimulus (e.g., photocatalysis). Many parameters can influence the physical antibacterial processes, such as the size, shape, and density of the surface nanotextures, and bacterial growth phases. Besides, different fabrication techniques for the physical antibacterial surfaces on Ti-based biomaterials are also summarized.