High-temperature thermo-mechanical experimentswere conducted to investigate the behaviors of self-developed new type Zirconium cladding under Loss-of-Coolant Accident (LOCA) conditions, including high-temperature oxidation, high-temperature creep, high-temperature burst, and embrittlement experiment. The high-temperature oxidation results show that the high-temperature oxidation rate of self-developed new type Zirconium cladding is comparable to that of ZIRLO, M5, and Zr-4 cladding when the oxidation temperatureexceeds1000°C, which could be estimated by Cathcart-Pawel model. Notably, the self-developed new type Zirconium cladding exhibits significantly lower high-temperature creepburst strain M5 and Zr-4 cladding, which could decrease fuel assembly blockage during LOCA accident, thus contributing to a more favorable outcome in LOCA analysis. Additionally, the embrittlementcriteria for Zirconium cladding, “peak cladding temperature ≤ 1204℃ equivalent cladding reacted ≤ 17%”, remains applicable to the self-developed new typeZirconium cladding.