The additive manufacturing of titanium/aluminum dissimilar metals can achieve the unification of lightweight and high strength. However, the connection between them poses difficulties. In this study, 6061 aluminum alloy was used as the substrate, and TC4 welding wire was employed as the cladding material for the laser - based additive manufacturing of titanium - aluminum dissimilar metals. Starting from the perspective of regulating the interface fusion ratio and reducing the generation of interface compounds to improve the interface performance, the process parameters were optimized. The optimal parameters were determined through single - factor experiments and non - linear regression analysis. Under this process, the interfacial tensile strength of the aluminum/titanium dissimilar metal structure was increased to 60.67 MPa. The microstructural evolution of the dissimilar metal interface under different additive manufacturing layer numbers was analyzed. The study found that with the increase of the additive