In order to elucidate the reaction mechanism between the rare earth elements Y and La and the nickel-based superalloy melt with Al2O3 ceramic crucible during the preparation process of components, in-situ drop-solution method was employed to study the interface reaction between the superalloy melt containing Y and La and the Al2O3 ceramic crucible at 1550℃.Research results indicate that, following the occurrence of interface reactions between the superalloy melt containing rare earth elements and the Al2O3 ceramic crucible, the surface quality of the alloy is favorable, with almost no adhesion of reaction products. When the alloy contains only Y, Y element reacts with Al2O3 to produce intermediate product Y2O3, which subsequently continues to react to form Y3Al5O12. Additionally, a small amount of Hf element reacts with Al2O3 to generate HfO2. When the alloy contains only La, La element reacts with Al2O3 to generate LaAlO3. La element inhibits the participation of Hf element in the interface reaction, and there is no generation of HfO2. However, when the alloy simultaneously contains Y and La, due to the higher reactivity of Y element, Y preferentially reacts with Al2O3 over La element, forming Y3Al5O12. As a result, the reaction between La element and Al2O3 is suppressed, effectively reducing the burning loss of La element.