The loading conditions of human bone in daily activities are complex. In order to obtain porous titanium alloy with excellent comprehensive performance for bone implants, it is necessary to comprehensively evaluate the different mechanical properties of porous structures. According to the different loading forms of human bones, the porous structures (TO-C, TO-T, TO-B) under compression, torsion and bending loads were designed by topology optimization method, and the obtained structures were reconstructed. The different mechanical properties of three topologically optimized porous structures were studied by finite element simulation of compression, torsion and bending. Finally, the compression specimens were prepared by Selective Laser Melting (SLM) technology, and the compression test was carried out. The results show that the TO-B structure has the best comprehensive mechanical properties among the three structures, and the compressive strength and compressive elastic modulus meet the needs of human bone implantation, which is the best porous structure type for orthopedic implants.