Based on TiAl turbocharger wheel with the diameter of 100mm after rig endurance test for total 240 hours, this paper evaluated the endurance of turbocharger wheel hub from the microstructure and mechanical properties. The microstructure and mechanical properties of the samples cut from the hub core of turbocharger wheel still retained a considerable level after endurance test. And the microstructure of the sample cut from the hub core of turbocharger wheel without rig test had an excellent stability after stress creep loading for 1000 hours at the actual working condition. So the hub of the turbocharger wheel had an condirable endurance that could meet the application requirement.