By the response curved surface technique (First, in line with actually chosen response curved surface regression and then in terms of the corresponding coefficient estimated by the least square method),it is possible to get the initial response curved surface regression equation. Based on the magnitude of the significance inspection value, the less significant variable of the coefficient can be eliminated by the lease square estimation ,the final curved surfac equation is established. In this paper, the response curved regression is chosen for making up for the deficiency of the orthogonal experiments in the research of the nanometer size TiO 2/UPR(Unsaturated Polyester Resins) composite. The results show that the response curved surface regression analysis technique is a good mathematics analysis method in the materials research.