7A60 alloys were prepared by spray deposition and casting techniques. The microstructures of the spray deposited and cast 7A60 alloys were studied using scanning electron microscopy, transmission electron microscopy, and X-ray diffraction. The results indicate that the cast 7A60 alloy exhibits coarse grains and macrosegregation. The microstructure of the spray-deposited Al-Zn-Mg-Cu alloy is composed of the refined, equiaxial grains without obvious segration. Compared with the traditional technique, the spray deposition technique increased cooling rate greatly, refine the microstructure of 7A60 alloy obviously.