By means of hot compression and tension test on a Gleeble-1500 equipment for the as-forged V-5Cr-5Ti alloys, the effect of the deformation temperature on the critical deformation and critical deformation resistance in the compression process were studied, its effect on the yield strength and percentage reduction of area in the tension process were also studied. The deformation microstructure of hot compression specimen was analyzed by OM. Results show that the V-5Cr-5Ti alloys have high deformation resistance and low plasticity. In order to improve the hot workability, the hot-working temperature range must be strictly selected and controlled. The optimum hot-working temperature range of V-5Cr-5Ti alloys should be 1150-1250 ℃, and the deformation amount should be below 30% to get satisfactory alloys.