Pt-W-Ru-Se catalysts with different Pt contents were fabricated by low-temperature synthesis and their catalysis effect on the oxygen reduction reaction was tested by the rotating-disk-electrode potential sweep method. The microstructure and surface composition of the obtained catalysts were characterized by XRD, EDS and XPS. Results show that Pt can greatly enhance the catalysis activity of W-Ru-Se to oxygen reduction. In particular, Pt-W-Ru-Se with 5% Pt (mass fraction, similarly hereinafter) is the most obvious one, whose catalysis activity to oxygen reduction is superior to that of W-Ru-Se and Pt in 0.5 mol·L-1 H2SO4. Its stability and resistance-methanol is better than that of Pt when there is methanol