In order to realize numerical simulation of plastic forming and to establish the reasonable hot formation process, the high-temperature compressive deformation behavior of AZ80 alloy was studied at various deformation temperatures and strain rates with Gleeble-1500. The experimental results show that the softening mechanism of dynamic recovery and dynamic recrystallization is a feature of high-temperature flow stress-strain curves of AZ80 alloy, and the peak stress increases with decreasing of the deformation temperature or increasing of the strain rate. Based on the true stress-strain curves, the established constitutive equation represents high temperature flow behavior of AZ80 alloy, and the calculated results of the flow stress are in good agreement with the experimental results of high temperature deformation of AZ80 alloy. Meanwhile, the obtained processing map of Dynamic Material Modeling (DMM) is used to analyze the deformation mechanism and the destabilization mechanism of AZ80 alloy; the optimal deformation processing parameters are the deformation temperatures ranging from 300 to 350 oC and strain rates ranging from 0.001 to 0.01 s-1, when the mechanical property of AZ80 alloy is taken into consideration.