The word “blisk” means that all the blades are integrated with a disk. The application of the blisk is a key technology for improving performance of aero-engines. High quality of the blisk conduces to expand its application. Because of a strong influence of microstructure homogeneity on the quality of blisk, the author gives attention to it. In this paper, a loss function (LF) referring to the concept of Taguchi method was proposed. In the proposed LF, the distribution homogeneity of thermomechanical parameters was employed to evaluate the microstructure homogeneity of TC11 blisk forging. Then, the forging process of the TC11 alloy blisk was analyzed using FEM technique. Based on the FEM simulation results, the microstructure homogeneity of TC11 blisk forging was evaluated. Experiment was performed to verify the proposed method.