The phase transformation process of dynamic model of L12 and DO22 phase in Ni64Al21V15 alloy at 1150 K was studied by micro-phase field model. The migration of Al, V and Ni atoms in the two phases in the different lattice faces and at different sites was analyzed, and its evolution was researched. The results show that there are two types of crystallographic orientation relationship between L12 and DO22: (001)L12→(001)DO22 and (001)L12→(100)DO22. In the structure transformation form L12 to DO22, the atomic ordering is proceeded on each plane as the atoms migrate between different planes, Al and V occupy the β and β1 sites prior to others, Ni occupy the α1 and β2 sites, and the nonordered domain gradually transforms to the L12 structure. Then, the atomic ordering is proceeded on each plane as the atoms migrate on planes only, Al occupy the β1 and α1 sites, V occupy the β and β2 sites, Ni mainly occupy the α1 site, and L12 structure transforms into DO22 structure