The direct cladding of Al2O3-13wt%TiO2 coating on Ti-6Al-4V alloy substrate was performed with coaxial laser cladding. OM and EMPA were used to examine the dilution characters, microstructure and element distribution of the cross-sections of cladding samples. The results show that after the irradiation the dilution zone (DZ) is likely to form the distinct pattern that at the edges of single clad pass the ceramic coating penetrates into the substrate, while in the middle of the pass the melting metal protrudes from the substrate into the ceramic coating. Moreover, there are many ceramic particles distributing in the DZ zone, and the layer is prone to produce more cracks with the cluster formation of the ceramic particles. The coating with low dilution and no obvious cracks is obtained by optimizing the processing parameters