Compressing bonding tests between pure titanium TA2 and 304L austenitic stainless steel have been carried out with the heating temperature 800, 850, 900, 950 °C by a thermal simulation machine. And then hot-rolling bonding test has been performed with the best heating temperature derived from the thermal simulation test results. The microstructure of the interfaces has been analyzed by optical and scanning electron microscopy (SEM). The interdiffusion of the elements and the reaction products at the interfaces have been evaluated by electron probe microanalysis (EPMA) and X-ray diffraction technique. And the shear strengths have been tested by a universal testing machine. Results show that the diffusion zone is dominated by σ-phase, σ′-phase, FeTi, NiTi and CrTi4. With a rise in the heating temperature the shear strength of the interface drops owing to an increase in the width of reaction products. The thermal simulation test sample heated at 850 °C gets the highest shear strength of about 147.5 MPa. And shear strength of the hot-rolling bonding plate heated at 850 °C is as high as 215 MPa.