The effects of three different heat treatments on microstructures and creep resistance of hot continuous rolled (HCR) GH4169 alloy were investigated. It is found that different heat treatments have an effect on grain size of HCR GH4169 alloy. The grain size of the sample after DA treatment is the smallest and that of the sample after HST treatment is the biggest. The content of d-phase increases with the increasing of the time of the solution heat treatment, and it mainly precipitates at the grain boundary. Under 650 °C/725 MPa experimental conditions, the HCR GH4169 after DA heat treatment has powerful creep resistance and long life time, while the HCR GH4169 after HST heat treatment has short life time. The fracture mode of creep specimens after heat treatments is intergranular fracture.