In term of newly developed titanium alloys Ti-6Al-4V-4Zr-Mo (Ti6441) modified from the commercial Ti-6Al-4V alloys, the adiabatic shear behaviors of equiaxed and lamellar microstructures were investigated. Unlike the Ti-6Al-4V alloys, Ti6441 alloys with the lamellar microstructure are less susceptive to adiabatic shear bands (ASBs), compared with the equiaxed one. In particular, the ASBs branch off in the lamellar microstructure, requiring additional energy by consuming metal bulk plastic deformation work. Besides, forced shearing experiment results show the lamellar microstructure exhibits outstanding dynamic ductility in contrast with the equiaxed one, though both microstructures perform the same strength value.