AlNiCrFexMo0.2CoCu (x=0.5, 1.0, 1.5 2.0) high entropy alloys were prepared by the method of powder metallurgy. Effects of Fe content on microstructure, hardness and comprehensive mechanical properties were investigated. The XRD results show that constituent phases change from bcc+fcc+ σ at x=0.5 to bcc+fcc at x=2.0. The hardness of the alloys varies from HBW3170 MPa at x=0.5 to HBW2290 MPa at x=2.0. The fracture strengths of all the AlNiCrFexMo0.2CoCu alloys are higher than 1100 MPa, and have a good plasticity.