Ti-29Nb-13Ta-4.6Zr alloys (wt%, TNTZ) were prepared by a spark plasma sintering (SPS) technique. The effects of the different sintering temperatures on the relative density, microstructure and mechanical properties of the alloys were investigated. In the sintering temperature range from 950 to 1150 oC, the alloys present a very high densification levels. All of the samples consist of β-Ti phase, Ti-Nb-Ta-Zr solid solution phase and some unmelted Nb, Ta, Zr metal particles. The alloys have a higher compressive strength, and they show a good room temperature compressive property. With the sintering temperatures increasing from 950 to 1150 oC, the relative density and the compressive strength of the alloys increase. The size of the matrix consisting of β-Ti phase and Ti-Nb-Ta-Zr solid solution phase increases and they bond further with each other. Furthermore, the size and the amount of the unmelted Nb, Ta, Zr metal particles decrease. The alloys exhibit low compressive elastic modulus in the range of 50~60 GPa, and it reveals the better mechanical compatibility.