The pulsed laser welding of 0.5 mm thick Hastelloy C-276 was carried out and the weld joint with less than 1 mm width was obtained, and then the tensile test and XRD analysis were conducted. The results indicate that the yield strength of as-welded sample is nearly the same as that of the base metal, and the tensile strength is just 88.6% of that of the base metal. In the fracture, the enrichment of brittle phase isn’t found. Their comparable yield strength is due to the similar effect of solution strengthening of the base metal and grain refining of the as-welded sample. The reduced tensile strength of the welded sample is attributed to the favorable formation of micro-fracture during the tensile test.