Gr.12 titanium extrusion tube billets were obtained adopting same mould and different extrusion processes, the defect parts of the extrusion tube billet wall were analyzed by SEM, EDS. The tubes obtained with different rolling processes were comparatively analysised by ultrasonic test and straightening. Titanium copper eutectic phenomenon is found in the defective parts of the extrusion tube billet. The surface quality of the extrusion tube billet is not stable when mold hardness HRC is less than 35 and surface roughness Ra is greater than 1.6 mm. The hardness of extrusion needle decreases rapidly and the inside surface quality is poor when the sheath is the copper material. The hardness of extrusion needle decreases slowly and the inside surface quality is better when extrusion temperature is 760～790 ℃, extrusion ratio is less than 18 and the sheath is the steel/copper composite. The surface quality of the finished product tube is better adopting pre-rolling by Q≤0.1, e≤35% and deformation degree per pass is less than 52%. The rolling and straightening cracking rate is less than 1‰ and ultrasonic inspection qualification rate can achieve to 95% using the above process for the mass production.