The ductile fracture of metal materials, which is the most common failure mode and important factor for hot workability in plastic forming, is always the research focus in the field of advanced plastic processing. A new fracture criterion is thus necessary to accurately predict the hot deformation fracture for the optimization of processes and improvement of products. In present study, a novel high-speed photography is introduced to determine the critical fracture strain of Ti60 high-temperature titanium alloy during hot compression deformation. This method can precisely captures the nucleation site and propagation process of cracking by two high-speed cameras fixed on opposite sides of the specimens, and thus is an efficient method to determination of the critical fracture strain in hot deformation processes. Based on Oh criterion, a new hot deformation fracture criterion considering strain rate and temperature effects is built and can be modeled as the function of Zener-Holloman parameter. By combining the DEFORM-3D simulation software and FROTRAN language, fracture initiation in the upsetting of large size Ti60 ingot can be precisely predicted which shows that the proposed prediction model is effective and practicable.