Ti-35Nb-7Zr-5Ta alloys were fabricated by spark plasma sintering (SPS) technology. The effects of different sintering temperatures on the relative density, microstructure and mechanical properties of the alloys were studied. The results show that the alloys are mainly composed of the mixed matrix which contains β-Ti phase, Ti-Nb-Ta-Zr solid solution phase, as well as some unmelted Nb and Ta metal particles in the sintering temperature range from 950 to 1150 oC. In addition, the alloys have a higher relative density and a higher compressive strength. With the increasing of the sintering temperatures, the mixed matrix bonds further with each other and its size increases. Meanwhile, the size and the amount of the unmelted Nb and Ta metal particles decrease. And the relative density and the compressive strength of the alloys are increased. The prepared alloys exhibit a low compressive elastic modulus in the range of 50~57 GPa, and they reveal an excellent mechanical compatibility. The results also show that the effect of sintering temperatures on compressive elastic modulus is very little.