Porous titanium with two different topology structures was designed and fabricated by a titanium mesh-stacking-sintering method. The microstructure and mechanical properties of the porous titanium specimens were investigated by scanning electron microscope (SEM) and electrical universal testing machine, respectively. The Young’s modulus and yield stress (σ0.2) were calculated from the stress-strain curves. The results show that the square pore distribution such as the staggered pore in the regular pore model can reduce the elastic modulus and yield stress as much as 74% and 10% at the same porosity, respectively. On the basic analysis from the analytical model, it is suggested that the bending and stress concentration are the main reasons of the elastic modulus and yield stress reduction