Seven zirconium alloys with copper and manganese additions in Zircaloy-4 were prepared by vacuum non-consumable arc melting method. The specimens were corroded by autoclave tests in lithiated water with 0.01 M LiOH at 360?C/18.6 MPa or in super-heated steam at 400 ?C/10.3 MPa. In comparison to the corrosion behavior of Zircaloy-4, the annealed Zircaloy-4 specimens obtained from commercial products and the remelted Zircaloy-4 specimens were also corroded together with the seven zirconium alloys specimens. The results show that the corrosion resistance was improved obviously by the addition of 0.05%~0.18% Cu or 0.07%~0.35% Mn, or 0.08%Cu and 0.09%Mn during the specimens corroded in lithiated water at 360?C. No transition occurred on the curve of the weight gain versus exposure time. Therefore the corrosion resistance of the seven alloy specimens was superior to that of Zircaloy-4. But the corrosion resistance of the specimens by the addition of Cu or Mn was worse than that of Zircaloy-4 during the specimens corroded in super-heated steam at 400?C. The tendency towards the degradation of corrosion resistance by the addition of Cu and Mn increased with the increase of the contents of Cu and Mn. The detrimental effect on the corrosion resistance by the addition of Mn is more obvious than that by the addition of Cu. The reason that the different effects on the corrosion resistance by the addition of Cu and Mn during the specimens corroded in different conditions was discussed and explained based on the relations between the anisotropic growth of oxide film and the addition of alloying elements.