How to improve the combines strength of bore and rim materials becomes most critical and practical problem for manufacting dual-alloys turbine disk. This research tried to address this issue. In this research, wrought superalloy GH4133B with equiaxed grains has been chosen as bore material and P/M superalloy FGH4096 with PPB nets has been chosen as rim material for dual-alloys turbine disk in present research. Electron beam welding was conducted on as-polished superalloys, and P/M-solidified-wrought (P/M-S-W) complex structure was obtained. Cylindrical compression specimens were machined from the central position of P/M-S-W complex structure. A series of isothermal compression tests were conducted on a thermo-simulation machine. Based on the compression results and the related analyses, plastic deformation and microstructure evolution of P/M-S-W complex structures have been investigated. This research has great effect on improving microstructure controlling theory and developing isothermal deformation technology for dual alloys.