Ti-6Al-4V alloy was thermal oxidized and subsequently vacuum diffused to prepare an oxidation coating. Dry sliding wear tests of the coating were performed at 400 ℃ in air on a high-temperature wear tester. The elevated-temperature wear behaviors and mechanism of coating were studied. The results show that the oxidation coating with a thickness of 250 μm was produced on Ti-6Al-4V alloy. The wear losses of oxidation coating were extremely low, compared with uncoated materials, its elevated-temperature wear resistance was noticeably improved. Tribo-oxide layers were always found to form on worn surfaces. The high wear resistance of coating could be ascribed to the integrated function of the hardened ceramic coating and protective tribo-layer. The predominant wear mechanism was delamination wear during dry sliding.