Dissimilar welding experiments of Hastelloy C-276/316L thin sheet was performed by Nd:YAG continuous laser. The element content changes of the weld under different laser offsets were studied and the effects of laser offset on the corrosion performance of Hastelloy C-276/316L weld in HCL solution were also investigated by means of polarization curves and electrochemical impedance spectroscopy. The results show that Ni, Fe and Mo contents change significantly with adjusting the laser offset, while Cr element content has no obvious change. When the laser offset is between 0.1~0.3 mm, the main element contents in the weld change slightly, the corrosion voltage and the charge transfer resistance are the largest and the corrosion current density is minimal. At this time the corrosion trend and the corrosion rate of the weld is minimum. Therefore, the corrosion resistance of the weld is the best under this parameter. When the laser offset changes from 0 to –0.2 mm, the content of Fe in the weld increases gradually, but the contents of Ni and Mo decrease. It is the main cause of the decrement of corrosion voltage and the charge transfer resistance. Corrosion current density increases and the corrosion trend as well as the corrosion rate of the weld increase gradually. As a result, the corrosion resistance of weld shows a trend of weakening under this parameter