In order to study the deformation resistance problem of a pure titanium coil of the finishing rolling section of hot continuous rolling process, according to the actual rolling process of industrial production, a hot compression test on pure titanium was carried out in the following conditions: the deformation temperature range was 700~800℃, the strain rate was 5~25s-1, the maximum deformation was 0.8. The results show that the flow stress of pure titanium decreases with the increase of deformation temperature, while increases with the increase of strain rate. The effect of temperature and strain rateon thedeformation mechanism was higher. The deformation was mainly dynamic recovery when the temperature was 700℃and the strain rate was 1s-1. The degree of dynamic recrystallizationincreased continuouslywith the increase of temperature and strain rate. the dynamic recrystallizationwas the most complete at the temperature of 800 ℃and the strain rate of 20s-1, whose microstructure wasthe most homogeneous. According to the true stress-strain data obtained from thermal simulation experiment, as well as considering the influence of chemical composition, and based on the deformation resistance model of Johnson-Cook model, a deformation resistance model was developed, which can reflect many factors. Comparing the calculated value of rolling force based on the deformation resistance model with the actual value verified the reliability of the model. The model provides an effective basis for finishing rolling technical control of pure titanium coil in the hot continuous rolling process.