Considering burr and collapse edge processing defects of Ti alloy honeycomb material using in aerospace with low stiffness and thin-walled, fixation and processing method should be improved. The material was treated by ice fixation method. CNC milling machine was used for the cryogenic processing. The honeycomb properties and reasons of machining defects were analyzed. Low-temperature milling mechanism of ice fixation was established. Results show that compared to the traditional processing way, the ice fixation milling surfaces have great improvement, and the processing defects are effectively suppressed. Moreover the cutting depth has greater influence on surface quality than spindle speed. The new method can improve the strength of honeycomb. Influence order of cutting parameters on the milling force can be obtained: cut deep is the largest and 3 times can be improved, followed by the spindle speed, feed speed which has minimal impact. Conclusion: for efficient processing of metal honeycomb material with small in-plane radial equivalent strength and low rigidity thin-wall, the ice fixation provides a new processing method.