Electron beam welding, electron beam isolation welding and electron beam isolation welding-brazing for the dissimilar combination of titanium alloy and stainless steel will be studied in this project. The present results show that the brittle intermetallic compound formed in the welding process is the key factor to influence the joint properties. The penetrated crack is formed in electron beam welding and electron beam isolation welding process directly leading to the joint unsuccessful. In electron beam isolation welding-brazing process, the joints has the characters of welding and brazing and the metallurgically bonded joint is achieved without melting the titanium alloy sheet. Ag and Cu as filler material exhibit good isolation layer which helps minimizing the formation of Ti/Fe intermetalics, aslo has an relaxation effect on the residual stress of the weld. The interalloying of dissimilar materials well controlling, a reaction zone is gained on the interface. The maximum tensile strength of titanium alloy/stailess-steel is up to 100MPa. The welded seams are good shape as well as the back of the joints and there is no crack and detected porosity in the joints through X-ray inspection.