Because the strength and stiffness of titanium alloy pipe are very high, it is difficult to be straightened. Considering the strengthening of material, the formula of bending moment in the process of pipe straightening was deduced. With the basic principle of straightening, the theoretical calculation model of straightening precision was deduced. With the help of the straightening precision calculation model, the amount of bending combination was optimized. The segmentation curvature straightening roller shape for titanium alloy tubes have been designed using the optimized combination of inflection. The reasonable value scope is presented after comprehensive analysis. It can provide reference for roll gap adjustment in practical production