2195 Al-Li alloy is identified as an ideal structural material for aerospace field, but limited research on its hot deformation behavior has been found in open publication. In this study, isothermal plane strain compression test was conducted on Gleeble-3500 thermal mechanical simulator, experimental temperature range from 400 ℃ to 500 ℃ and strain rate various from 0.01 s-1 to 10 s-1. The results show that flow stress decreases with increasing temperature and decreasing strain rate. Constitutive model based on the hyperbolic-sine equation was established to describe relationship between flow stress and deformation temperature, strain rate. The apparent activation energy of plane strain compression was estimated to be 217 KJ / mol. To evaluate the hot workability of this alloy, the processing maps at strains of 0.5 and 0.7 were constructed on the basis of dynamic material model and Prasad’s instability criterion. Optimum parameters were obtained in the temperature of 475~500 ℃, strain rate of 0.01 s-1 for plane strain compression.