Zr-0.8Sn-1Nb-0.3Fe zirconium alloy sheets were prepared by different heat treatment processes, then OM and TEM were used to analyze the microstructure of the samples, and static autoclave tests were carried out in 360℃/18.6MPa/0.01mol/L LiOH solution and 400℃/10.3MPa superheated steam to investigate the corrosion behavior. The results showed that the second phase particles(SPPs) are mainly C14 type Zr(Nb,Fe)2 with a HCP structure, and the uniformity of SPPs distribution gradually become worse when the hot-rolling temperature increases from 600℃ to 700℃. Aging treatment before hot-rolling not only improved the uniformity of SPPs distribution, but also promoted the diffusion of Nb, which increased the amount of βNb SPPs. Extension of final annealing time had little influence on size and distribution of the SPPs, but increased the Nb/Fe ratio in the SPPs. After long time corrosion tests, the corrosion resistance became worse when the hot-rolling temperature increased in both corrosion conditions. Aging treatment before hot-rolling could increase the corrosion resistance. Extension of final annealing time also could increase the corrosion resistance in LiOH solution, but decrease the corrosion resistance in superheated steam. The relationship between microstructure and corrosion resistance was discussed, and the size, distribution and the Nb content of SPPs were considered to be the main reason for the difference of the corrosion resistance of Zr-Sn-Nb-Fe zirconium alloys.