The mathematical models on the needling processing parameters and the multiple mechanical performances of needling C/C composites were established based on Response Surface Methodology by the design-expert system. The response surface models of tensile strength, shear strength,tensile strength and shear strength ratio,compression strength and preform density have high fitting degree, P of which is less than 0.05 and R-Squared of which is higher than 0.82. These response surface models are able to design and predict the needling processing parameters and the mechanical performances of needling C/C composites with reasonable accuracy. The comprehensive optimization results of multiple response targets of needling C/C composites show that: when the needling density is 12.18Pin/cm₂, the needling depth is 11.68mm and the Non-woven density is 90.55g/m₂, the comprehensive mechanical performances of needling C/C composites are the best. At this point, the tensile strength is 116.49MPa, the bending strength is 121.48MPa, the shear strength is 19.41MPa, the compression strength is 160.88MPa and the preform density is 0.42g/cm₃.