The effect of Y2O3 crucible on the purification of Ni3Al-based superalloy IC21 scraps during Vacuum Induction Melting was investigated. Different purification results were compared when using MgO crucible and Y2O3 crucible. The results indicated that Y2O3 crucible was more effective for reducing the content of hydrogen, nitrogen and oxygen. Hydrogen, nitrogen, and oxygen content using Y2O3 were about 50%, 80%, and 80% lower compared with MgO crucible, to 0.5 wppm, 1 wppm and 2 wppm in IC21 scraps, respectively. When melting temperature was above 1550°C or reaction time exceeded 5 minutes, it had limited impact on dehydrogenation and denitrification process when using Y2O3 crucible. Melting for 5 minutes at 1750°C or melting for 30 minutes at 1650°C, the content of oxygen reached the highest level, which was 6 wppm.