In view of the problem that TC4/304 are difficult to be directly bonded by hot-roll, a TC4/304 composite plate was prepared by hot-roll bonding in a vacuum using a DT4 interlayer. The effects of the DT4 interlayer and the bonding temperature on the mechanical properties and interfacial structure of the composite plate were investigated by scanning electron microscopy, energy spectrometry, X-ray diffractometer and tensile-shear testing. The results show that, when the intermediate layer of DT4 is added, at a 20% reduction ratio, when the bonding temperature is between 750 ℃ and 950 ℃, the shear strength of the bonding surface increases with the increase of the bonding temperature. At 950 ℃, the bonding effect is best, the shear strength of the bonding interface reaches 248 MPa. At 1 050 ℃, formation of intermetallic compounds at the interface between DT4 and TC4 decreases the bonding strength.