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Development and degradation behavior in vitro of Mg-based foam biomaterials for bone tissue engineering
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Affiliation:

Northeastern University

Clc Number:

R622,TF822,TG172

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    Abstract:

    Mg-based foam biomaterials were prepared by a melt foaming process, wherein a Mg-Ca alloy was used as the matrix material, hydroxyapatite (HA) as the tackifier, MgCO3 as the foaming agent. The Mg-based foam biomaterials with uniform structure were tested to investigate their biodegradable behaviors. The biodegradable property of the Mg-based foam was mainly characterized by microstructure observation, immersion tests and electrochemical measurements. The results show that the weight loss rate increases with the increasing porosity of the specimen over a fixed period of time. The weight loss rate of the specimen without HA particles is much higher than that of the specimen with HA particles. Meanwhile, the open porosity of the Mg-based foam biomaterial increases with immersion time. Both the total porosity and added HA content have an important impact on the open porosity of the Mg-based foam biomaterial. Over a fixed period of time, the open porosity of the Mg-based foam biomaterial increases with the increase of the total porosity. Mg-based foam biomaterials with added HA exhibit higher corrosion resistance than Mg-based foam biomaterials without HA in simulated body fluid (SBF) media.

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[Wenzhan Huang, Hongjie Luo, Yongliang Mu, Jianrong Xu. Development and degradation behavior in vitro of Mg-based foam biomaterials for bone tissue engineering[J]. Rare Metal Materials and Engineering,2019,48(10):3081~3087.]
DOI:10.12442/j. issn.1002-185X.20181002

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History
  • Received:September 30,2018
  • Revised:November 11,2018
  • Adopted:November 12,2018
  • Online: November 01,2019
  • Published: