The deposited sample of x × y × z (40 mm × 5 mm × 60 mm) Ti-48Al-2Cr-2Nb alloy was successfully fabricated by laser metal deposition. The microstructure, phase composition, grain orientation and fracture morphology of the deposited sample were analyzed by optical microscope (OM), scanning electron microscope (SEM), X-ray diffraction (XRD), transmission electron microscope (TEM) and backscattering diffraction (EBSD). The hardness distribution at different positions of the deposited sample was measured by Vickers hardness tester. The tensile properties of the deposited sample in Z direction were measured by tensile machine. The results show that the well-formed deposited sample is obtained under the optimum process parameters, and no surface cracks are found after penetration detection. The microstructure of the deposited sample is composed of α2+γ lamellar colony and a small amount of bulk γ phase. For as-deposited γ-TiAl alloy, the room-temperature tensile strength along the Z direction is 425 MPa and the elongation is 3.3%. The fracture morphology of tensile specimen is quasi-cleavage fracture.