In this work, the grain boundary characteristics distribution and texture evolution of GH3625 alloy tubes during short-flow manufacture process (hot extrusion, solution treatment, cold rolling and annealing treatment) were investigated by electron backscatter diffraction (EBSD) and orientation imaging microscopy (OIM) technique. And the cold and hot plastic deformability of alloy tubes via analyzing the Schmid factor and Taylor factor were further studied. The results show that the grain boundary character distribution in the short-flow manufacture process of GH3625 alloy tubes is optimized through annealing twins related to Σ3_ⁿ grain boundaries rather than deformation twins. The Brass texture {110}<112> and fiber texture <111>//RD is generated in the hot extrusion/cold rolling deformation process of the alloy tubes, while the {110}<110> texture and Brass-R texture {111}<112> appear during solution/annealing treatment. GH3625 alloy tubes preferentially plastic deformation in the extrusion direction (RD) during hot extrusion, while plastic deformation occurs in the direction perpendicular to the rolling direction during cold rolling. At the same time, comparing the average Schmid factor value m_s and Taylor factor value M_T of GH3625 alloy tubes during hot extrusion and cold rolling deformation, it is found that the plastic deformability of cold rolling is worse than hot extrusion, and higher deformation work is needed.