In order to prepare Monel alloy porous filtration material, Monel powder was used as raw material and K2CO3 as a space holder, the porous Monel samples with different porosity were fabricated by a sintering-dissolution process. The influence of space holder, compacting pressure and sintering temperature on the porosity, cell size and permeability of samples were investigated and discussed. The experimental results show that the porosity of samples is in range of 31%~46%, while the volume fraction of space holder between 20 vol.% and 40 vol.%. While compacting pressure in the range of 200~400 MPa, the porosity, cell size and permeability of samples decrease with compacting pressure increasing; while sintering temperature in the range of 850~1000 ℃, the cell size and permeability increase first, then slowly decrease with the sintering temperature increasing, the peak value at 950 ℃.While the volume fraction of space holder is 30%, compacting pressure 200 MPa, sintering temperature 950 ℃, the porosity, maximum cell size and permeability of the porous Monel sample are 37%, 21.5μm, 76.77 m3/(h?kPa?m2), respectively.