The high-quality GH4169 nickel-base superalloy has higher Nb content, and its microstructure is more sensitive to the process parameters,especially after δ phase aging (DP) treatment, thus it is necessary to study its hot deformation behavior. In this paper, the hot deformation behavior of GH4169 alloy, have been studied by isothermal compression tests at the temperatures of 980-1070°C and strain rates of 0.001-1 s-1. The results show that the deformation temperature and the strain rate have obvious effects on the flow characteristic. Constitutive model was established based on sine-hyperbolic Arrhenius kinetic rate equation, the value of average activation energy ( 528.24 kJ/mol) of GH4169 alloy is obtained in present study,increase of Nb content will increase the modified activation energy significantly. Hot workability is interpreted by processing maps. The optimum hot working conditions for GH4169 ally was low temperature with low strain rate and high temperature with high strain rate area.