The new TiZrHfNbSc refractory high-entropy alloy was prepared by vacuum arc melting with argon shield. The microstructure were studied by XRD, SEM and DSC, the hardness and mechanical properties were measured by vickers microhardness tester and micro-control electronic universal testing machine. The results showed that the TiZrHfNbSc refractory high-entropy alloy had a single disordered BCC solid solution structure with the lattice parameter a=3.443? .The alloy density was 7.16 g/cm_³ and the Vickers microhardness was 380. The alloy had high compression yield strength(σ_{0. 2}=650MPa) and the compression deformation rate is more than 60%.The strengthening mechanism of the alloy is solid solution strengthening.