The isothermal compression tests of Ti60 alloy were conducted on the Thermecmaster-Z thermal simulator at deformation temperature of 600～950℃, strain rate 0.001～10s_^-1. The hot deformation behavior of Ti60 alloy were investigated, by analyzing the flow stress behavior, calculating the strain rate sensitive exponent m and strain hardening exponent n, along with the processing map and deformation microstructure, to optimize processing parameter. The results show that the flow stress-strain curve of Ti60 alloy presents flow steady state and flow softening respectively at different processing parameters. The strain rate sensitivity exponent m increases with the increase of deformation temperature and decrease of strain rate. The strain hardening exponent n decreases with the increase of deformation temperature. With the increase of strain rate, n increases in the low strain rate (0.001～0.1s_^-1) and decreases in the high strain rate (1～10s_^-1). With the increase of strain, n decreased slowly at the low strain rate (0.001～0.1s_^-1), the high temperature (800～950℃), while which decreased significantly at the high strain rate (1～10s_^-1) , the high temperature section (800～950℃) and all the strain rates (0.001～10s_^-1), the low temperature (600～750℃). Ti60 alloy has two peak power dissipation efficiency regions, whose corresponding processing parameter Windows : temperature 725～875℃, strain rate ≤0.003s_^-1 and temperature 875～938℃, strain rate ≤0.04s_^-1, respectively. Considering the flow stress behavior, strain rate sensitivity exponent m, strain hardening exponent n and processing map, the optimal thermal processing parameters of Ti60 alloy: temperature 800～875℃, strain rate 0.001～0.003s_^-1, or temperature 875～938℃, strain rate 0.001～0.04s_^-1.