In recent years, material design approach is being changed from trial and error experiments to integrated calculation based on computational models in synergy with the rapid development of Materials Genome Initiative and Integrated Computational Materials Engineering (ICME). High specific strength, outstanding corrosion resistance and good fatigue properties make titanium alloys widely used as structural material for aerospace and implants for biomedical area. This paper reviews the development history and alloying methodology of ? titanium alloys. The near ? alloys with addition of multi elements such as Al, Zr, Mo, V, Cr and Fe is becoming more and more attractive. Several design approaches are summarized in this paper where include Mo equivalent method, e/a method and “cluster- plus-glue-atom” model based on empirical methodology, and also include some method based on computational thermodynamics or first principles. Finally, the integrated calculation model of computational design used for hierarchically structured materials is discussed in detail and the potential application of this approach in titanium alloy design is analyzed.