In present work, a non-isothermal simulated hot compression test is designed to investigate the effect of final forging temperature on hot deformation behavior of GH4738 superalloy. Microstructure observation is carried out to explore the effect of final forging temperature on homogeneity of microstructure and microstructure heredity in following heat treatment process. The results show that in the condition of same initial forging temperature, the dynamic recrystallization of GH4738 superalloy will be inhibited when the final forging temperature is too low. The fraction of dynamic recrystallization is relatively low and the flow stress keeps increasing during hot compression. The less developed dynamic recrystallization microstructure tends to develop into mischcrystal structure in the following heat treatment process and can influence the homogeneity of microstructure. Hence, the final forging temperature should be rational controlled to improve the microstructure homogeneity of forgings during hot deformation.