A new type of high strength and tough powder titanium alloy for Marine use was prepared by hot isostatic pressing (HIP) near net forming process using pre-alloyed powder. The interface reaction between titanium alloy and low carbon steel cladding was studied. Results show that there is a wavy interface between titanium alloy and low carbon steel capsule and the thickness of interfacial reaction layer is 8 microns. Alloying elements Al, Mo and V in titanium alloy diffused into low carbon steel to a certain extent, while matrix elements Ti and Fe of the two materials diffused significantly less than the former. After selective chemical washing, The capsule was removed, and the thickness of interfacial reaction layer was reduced by 2.5μm, but the interface was still wavy. Subsequent sand blast could not only reduce the thickness of the interfacial reaction layer but also make the interface flat.