In order to improve the friction and wear behavior and high-temperature oxidation resistance of titanium alloy, AlCoCrFeMoVTi high-entropy alloy (HEA) were designed and AlCoCrFeMoVTi HEA coatings were prepared by laser cladding technique on Ti6AI4V titanium alloy (TC4) surface. The phase composition and microstructure of AlCoCrFeMoVTi HEA coating were analyzed by means of X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The microhardness of coatings was measured by HDX-1000 Vickers hardness tester. The wear resistance and high-temperature oxidation resistance of the coating were tested by UMT-3 friction tester and GSL-1400X tubular resistance furnace. The results show that the AlCoCrFeMoVTi HEA coating is mainly composed of face centered cubic (FCC) structures and body centered cubic (BCC) structures binary eutectic phase. The maximum microhardness of the coating was 1099 HV0.2, which was 3.29 times that of TC4 titanium alloy substrate. The friction coefficient of the coating was 0.31, and the wear volume was 1.79×10-4 mm3, respectively 59.62% and 12.01% of the matrix. After oxidation at 800℃ for 50 h, the oxidation weight of the coating was 1.49 mg, which was only 16.37% of the matrix. Laser cladding AlCoCrFeMoVTi HEA coating can significantly improve the friction and wear behavior and high-temperature oxidation resistance of Ti6Al4V titanium alloy.