The Ti45Zr35Cu5Ni15 bulk metallic glass with a small amount of nanocrystalline was prepared by copper mould injection casting. The dynamic compression properties of the alloy was investigated with the split Hopkinson pressure bar (SHPB) under high strain rates at room temperature (25℃) ,-80℃ and liquid nitrogen temperature (–196 ℃), respectively. The morphology characteristics of the compression fracture were observed by field emission scanning electron microscope (SEM) with energy spectrum. Comparative analysis shows that the material exhibited maximum dynamic compressive strength and plastic deformation at -80℃, and the maximum compressive strength reached 2378MPa when the plastic strain reached 12% , which exhibited excellent mechanical strength and toughness. Furthermore , uncommon profuse wrinkles were also found on the fracture surface. The mechanical properties of the materials were similar at room temperature and liquid nitrogen temperature. The maximum compressive strength was around 1600MPa while the plastic strain reached about 8%, and the river pattern on the fracture surface of the material could also be observed. In addition , the material showed strain softening at room temperature and strain rate strengthening at low temperature to a certain extent.